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"We believe these reports are a step forwards in meeting an unmet need for a more informed and personalised approach to weight management." One commentator on the findings, Dr Marie Spreckley of the University of Cambridge, said that "genetics is only one part of a much more complex picture." The magnitude of the genetic effects is small in clinical terms, she contends, pointing out that in clinical trials typical weight loss with these medications is often in the range of around 10%-15%
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When semaglutide is used with insulin or sulfonylureas, there is an increased risk of hypoglycemia, and dosage adjustments of these medications may be necessary
The significant difference is that Ozempic is approved to address insulin resistance for those with Type 2 Diabetes and not for weight loss, whereas Wegovy is approved as a weight loss treatment for those who qualify
