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A meta-analysis of serum and plasma OPN published in 2014 found pooled specificity and sensitivity of 0.81 (95 percent confidence interval: 0.79-0.84) and 0.57 (95 percent confidence interval: 0.52-0.61), respectively, with significant heterogeneity across the nine studies

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Endocrinology 132 : 19391944

Reissland says all the fetuses had a healthy birth weight but the images showed that smoking affected "fine grain behaviors." "Normal fetal behavior shows fewer movements but the images suggest that fetuses in smokers are less mature in their behavior," Reissland told USA TODAY Network

They're more pliable and produce less harsh smoke