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Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency

Subsequently, NP4-Cy7.5 was intravenously injected into BALB/c mice, and the biodistribution of nanoparticles in mice was observed using an in vivo imaging system (IVIS)

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First, inhibition of the Xc system has been shown to disrupt GSH and GPX4 synthesis by inhibiting cysteine uptake, lowering the activity of antioxidant products and increasing the expression of lipid peroxides, eventually leading to ferroptosis [22, 23]