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According to the Rybelsus Summary of Product Characteristics (SmPC) published on the Electronic Medicines Compendium (EMC), oral bioavailability remains relatively low compared to the injectable form, and the tablet must be taken on an empty stomach with no more than half a glass of water (approximately 120 ml), with the patient remaining fasting for at least 30 minutes afterwards, to maximise absorption

doi: 10.1016/j.peptides.2018.04.008 40 DavidsonIWSalterJMBestCH

He emphasizes that these medications are not interchangeable without medical advice due to differences in dosing schedules and potential side effects

GLP-1 is an endocrine hormone secreted by enteroendocrine L-cells located in the distal jejunum, ileum and colon that express the glucagon gene and produce proglucagon (Lee et al., 1990)

Nat Rev Endocrinol 17(3):150161