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Cocaine acts as a true competitive inhibitor that directly occupies the S1 central substrate site, physically blocking the reuptake of endogenous monoamines

CYP2R1 expression was not seen in FL83B mouse hepatocytes) and 1--hydroxylase (CYP27B1), along with the increased expression of 24-hydroxylase (CYP24A1), was observed in GSH-deficient hepatocytes

Group 3 (T200): Animals were administered with 100 mg/kg bw of AlCl 3 for 45 days, which was succeeded by 200 mg/kg bw of FR leaf extract for 15 days