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Contrave dampens this brain signal and makes eating fatty food or sugary food less satisfying (less pleasurable) and reduces the urge to comfort eat or crave these foods. Through this study, researchers make the case for a combined approach, using both gut hormone analogs like GLP-1s, and NB-ER at the same time, to treat obesity Combining NB-ER with GLP-1 makes mechanistic sense because GLP-1 primarily makes a person feel full faster and decreases hunger, while NB-ER reduces food cravings, Hussain explained
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Common contributing factors include: Chronic constipation and straining during bowel movements Prolonged sitting on the toilet Diarrhea and frequent bowel movements Increased intra-abdominal pressure Given that Zepbound commonly causes both constipation (in approximately 16-17% of patients) and diarrhea (in about 18-24% of patients), these gastrointestinal effects could theoretically contribute to hemorrhoid development or worsening in susceptible individuals
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