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The most common reason for discontinuation is not lack of efficacy but side effects during titration, cost, or loss of insurance coverage

Across major subgroups, including age and sex, the results were consistent

Common GLP-1-based medications include: Semaglutide (brand names: Wegovy, Ozempic) Tirzepatide (brand names: Zepbound, Mounjaro) Retatrutide (currently an investigational medication and not yet FDA-approved for weight loss) These medications work best when combined with a healthy diet, regular physical activity, and sustainable lifestyle changes

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