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J Pharm Sci 1976;65:1218-21

Very long-term continuous use (months to years) is not well-characterized and should be undertaken only with appropriate oversight, full tracking, and clear research objectives that justify the extended duration

AndersonCLiHCheboiwoVFisherSChepkemoiERuttoEet alUncomplicated gastroschisis care in the US and Kenya: treatment at two tertiary care centers

Pedersen SS, Prause M, Srensen C, Strling J, Moritz T, Mario E, Billestrup N

In particular, these adducts repress the unduly stabilized -catenin from entering nucleus where it normally binds to TCF/LEF initiating the target gene transcription that encodes intrinsic promoting factors for tumour progression [121, 122]