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Licensed pharmacological options currently available in the UK include: Orlistat : Reduces dietary fat absorption

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13.8%: Broad eligibility + perfect adherence 10.4%: Broad eligibility + real-world adherence 8.1%: Narrow eligibility + perfect adherence 6.1%: Narrow eligibility + real-world adherence Even with cost-sharing (e.g., $90 copay), premium increases only drop by 12 percentage points

However, coverage often applies when the injections are prescribed for type 2 diabetes