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In an AD amyloid mouse model lacking BACE1 palmitoylation, reduced BACE1-containing localization within dystrophic neuronal synapses around amyloid plaques led to a significant reduction in local amyloid load, which alleviated cognitive dysfunction in mice (169)

Abstract Background Chronic kidney disease (CKD) is estimated that by 2040, it will be the 5th highest cause of years of life lost globally due to the aging population and the rising prevalence of age-related diseases such as hypertension and diabetes

Within the HT-22 cell model, melatonin enhanced cell proliferative capacity, decreased apoptosis, and lowered ROS generation (Sun et al., 2024b)

Raimo et al., 2021)

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