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Specifically, they show an early increase in DA neuron counts in the SNcVTA region and elevated striatal DA levels preceding chorea and non-motor symptoms 46

Otherwise its not melena or its derivatives (melenic, melanotic, melenatonic

endotoxin) can trigger systemic inflammation that further exacerbates neuroinflammation, illustrating how brain disorders are not confined to the CNS but involve a systemic network including the gut ecosystem [16]

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