[DOI] [PubMed] [Google Scholar] 157.Ohno T., Yanai M., Ando H., Toyomasu Y., Ogawa A., Morita H., Ogata K., Mochiki E., Asao T., Kuwano H
Cell culture studies using adipocytes have shown that NNMT overexpression promotes lipid accumulation and insulin resistance, while NNMT knockdown or inhibition increases NAD+ levels, activates SIRT1, enhances mitochondrial respiration, promotes expression of thermogenic genes including UCP1, and drives white adipocyte browning toward a beige phenotype
PMID: 32697320, PMCID: PMC7376388, DOI: 10.1001/jamanetworkopen.2020.11127
A strategic leader with demonstrated success in recognizing and maximizing individual, agency, and cross-functional team strengths, Paige is part cheerleader and change agent, bringing innovative and customer-focused approaches through disrupting the status quo
Peripherally, pancytopenia is most often observed, but only 12 of the major cell types (erythrocytes, leukocytes, platelets) may be depressed in some cases