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In addition to its effects on GH release, MK-677 also activates the secretion of insulin-like growth factor 1 (IGF-1), which plays a role in cell growth, replication, and repair

5-Amino-1MQ selectively inhibits NNMT (IC50 = 1.2 M), an enzyme that consumes nicotinamide by methylating it

The reality is there is no weight loss easy button, and committing to an expensive, life-long medication with side effects isnt easy, either

Okamoto R, Tsuchiya K, Nemoto Y, Akiyama J, Nakamura T, Kanai T, et al

IGF-1 is necessary as well as sufficient in muscle growth (anabolic) and has been shown to also be highly anti-catabolic agent as well