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It also affects telomere integrity and sleep quality

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This may explain why side effects are relatively rare compared to pharmaceutical approaches that introduce foreign signaling molecules

Finally, if the serum cobalamin concentration at the time of reevaluation is subnormal, further work-up is required to definitively diagnose the underlying disease process and cobalamin supplementation should be continued weekly or bi-weekly (for parenteral supplementation) or daily (for oral supplementation)

[DOI] [PubMed] [Google Scholar] 59.Hareuveni M, Gautier C, Kieny MP, Wreschner D, Chambon P, Lathe R