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10.1002/cam4.7082 57 HuangD.YangB.YaoY.LiaoM.ZhangY.ZengY.et al (2021)

Excessive generation of reactive oxygen species activates redox-sensitive signalling pathways, including NF-B, leading to sustained release of pro-inflammatory cytokines such as TNF-, IL-6, and IL-1, which impair fibroblast function, collagen synthesis, and neovascularisation

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Compared with acute wounds, DFU are characterized by persistent chronic inflammation, impaired angiogenesis, stagnant re-epithelialization, and difficult remodeling [11, 12]

With a range of scientific data highlighting chemical exposures during pregnancy as a critical window of vulnerability, public awareness of these threats is growing