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It is indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity such as hypertension, dyslipidemia, obstructive sleep apnea, or cardiovascular disease

For this experiment, we used the synthetic disulfide cross-linked A dimer [AS26C] 2 , which was shown to be a potent neurotoxic A-agent in various assays, including neurite outgrowth 3 , the induction of long-term potentiation (LTP) 36,37 and neuronal hyperactivation 10,18

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