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Klowan, 72, a lifelong Cumberland resident who lives on Reservoir Road, was named the winner of Rhode Islands famous Southern New England Giant Pumpkin Growers Annual Weigh-Off in Warren on Sunday, his pumpkin weighing in at 2,074.5 pounds, more than 400 pounds heavier than his previous personal best

Other mechanisms include increased insulin resistance induced by high-dose glucocorticoids that increases intra-portal insulin, decreases IGFBP-1 that increases free IGF-I, and direct glucocorticoid effects in increasing hepatic IGF-I synthesis and decreasing hepatic insulin clearance (105)