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The STEP-1 trial demonstrated mean weight loss of 14.9% with weekly semaglutide.[1] The SURMOUNT-1 trial showed 20.9% with tirzepatide.[2] The SELECT cardiovascular outcomes trial revealed a 20% reduction in major adverse cardiovascular events among non-diabetic patients with obesity.[3] These are not supplements

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Certain GLP-1 receptor agonists appear capable of crossing into the brain, which raises the possibility of direct neurological effects

Bowden, J., Davey Smith, G

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