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G6PD catalyzes the rate-limiting step of the PPP, effectively diverting G6P away from glycolysis toward 6-phosphogluconate, thereby promoting NADPH generation and glutathione synthesis ( Figure 6B )
doi: 10.1186/s12974-018-1078-8 195
The mechanism of EtOH-induced depletion of GSH may involve the direct conjugation of GSH with acetaldehyde (AcH), the reactive intermediate of EtOH oxidation [48, 49]
Type: Coenzyme / Dinucleotide
Funding This work was supported by National Natural Science Foundation of China (81971956 and U1704189) and Natural Science Foundation of Henan Province of China (212300410070)
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