Altered striatal glutathione metabolism affects the dopaminergic system A sustained increase in extracellular DA induces selective degeneration of its target neurons, SPNs 35
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Moreover, although the microbiome reached an adult-like stability at around 2 years of age, important taxonomic and functional changes did occur both before and after adolescence
a strong feeling of discomfort in the chest and abdomen as well as a feeling or sense of anxiety and fatigue
These modifications in metabolism pathways resulted in a substantial increase in the levels of 48 metabolites such as Xanthine, ascorbate, Cys-Gly, kynurenine, phenylalanine, 5-hydroxykynurenine, and others as outlined in Supplementary Figures 5A, B