MGMT is potentially important for guiding the use of the chemotherapeutic agent temozolomide (TMZ) in GBM, and MGMT promoter methylation is significantly associated with improved overall survival in GBM patients (Sareen et al., 2022)
143 Besides, using 13 C-labeled metabolic flux assays, researchers found that the preference for glycolysis and OXPHOS varies across variant stages of the cell cycle in breast cancer cell lines
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